29/09/2025

๐Ÿ’œ The Epilepsy-Friendly Power of Purple

There are many important benefits from eating  Anthocyanins including

ยท        Protection against hearts disease

ยท        Improved immune function

ยท        Protection against cancer

ยท        Improved cognitive function


But research has shown that this flavonoid could majorly help prevent and manage epilepsy.

STUDIES:

BMC PUBLIC HEALTH 2024:
Therefore, embracing a diet rich in antioxidants could be beneficial in preventing epilepsy. This finding holds considerable potential for shaping future strategies in both epilepsy prevention and treatment.

Brain Sciences 2023:
In this review paper, we present the preclinical research findings that used flavonoids to target neuroinflammatory pathways in epilepsy.

Preclinical findings showed that flavonoids could reduce the production of pro-inflammatory cytokines by directly affecting inflammatory regulators like NF-kB and NLRP3 inflammasomes and altering the activity of resident immune cells in the brain, along with the proteins and signaling pathways that affect their activation. In these studies, flavonoids also prevented a long-term neuroinflammatory response by increasing the levels of anti-inflammatory cytokines and decreasing the levels of pro-inflammatory mediators such as COX-2, NOS, and others. 

Frontiers in Pharmacology 2025:
Oxidative stress and mitochondrial dysfunction play critical roles in the pathophysiology of epilepsy, contributing to neuronal hyperexcitability and cell death. Preclinical studies have provided substantial evidence that antioxidant therapies can mitigate these pathological processes, reduce seizure activity, and protect neuronal integrity. Antioxidant therapies represent a promising adjunctive strategy in the management of epilepsy. By targeting oxidative stress and mitochondrial dysfunction, these agents have the potential to modify disease progression and improve patient outcomes.

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